Dubey Prakash K, Kumar Arun
Department of Anesthesiology & Critical Care Medicine, Indira Gandhi Institute of Medical Sciences, Patna, India.
Anesth Analg. 2005 Oct;101(4):1060-1062. doi: 10.1213/01.ane.0000166951.72702.05.
Pain on injection of propofol continues to be a problem for anesthesiologists. A lipid-free formulation of propofol and a propofol emulsion containing medium-chain triglyceride have become available in the Indian market. We performed this study to assess the pain on injection of propofol emulsion containing medium-chain triglyceride as the lipid carrier and lipid-free propofol formulation. One-hundred-thirty adult patients were randomly assigned to one of two groups: Group I received propofol emulsion containing medium-chain triglyceride and Group II received lipid-free propofol. One fourth of the total calculated induction dose was injected over 5 s in the largest vein on the dorsum of a hand. Pain was assessed using verbal response and behavioral signs. Both formulations caused pain on injection. However, the lipid-free propofol solution produced frequent (89%) and severe pain on injection compared with the emulsion containing medium-chain triglyceride (40%).
Pain on injection of two formulations of propofol was compared. A lipid-free formulation produced more pain on injection as compared with the emulsion containing medium-chain triglyceride.
丙泊酚注射疼痛仍是麻醉医生面临的一个问题。不含脂质的丙泊酚制剂和含中链甘油三酯的丙泊酚乳剂已在印度市场上市。我们开展这项研究以评估含中链甘油三酯作为脂质载体的丙泊酚乳剂和不含脂质的丙泊酚制剂的注射疼痛情况。130例成年患者被随机分为两组：第一组接受含中链甘油三酯的丙泊酚乳剂，第二组接受不含脂质的丙泊酚。将总诱导剂量的四分之一在5秒内注入手背最大的静脉。使用言语反应和行为体征评估疼痛。两种制剂注射时均引起疼痛。然而，与含中链甘油三酯的乳剂（40%）相比，不含脂质的丙泊酚溶液注射时频繁出现（89%）且疼痛剧烈。
比较了两种丙泊酚制剂的注射疼痛情况。与含中链甘油三酯的乳剂相比，不含脂质的制剂注射时疼痛更剧烈。
