FOXP3，一种成人T细胞白血病/淋巴瘤亚群的特异性标志物。

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma.

作者信息

Roncador G, Garcia J F, Garcia J F, Maestre L, Lucas E, Menarguez J, Ohshima K, Nakamura S, Banham A H, Piris M A

机构信息

Monoclonal Antibodies Unit, Biotechnology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

出版信息

Leukemia. 2005 Dec;19(12):2247-53. doi: 10.1038/sj.leu.2403965.

DOI:10.1038/sj.leu.2403965

PMID:16193085

Abstract

FOXP3 is a forkhead transcription factor family member, implicated in T-cell regulation, activation and differentiation. FOXP3 has been shown to be a master control gene for the development and function of CD4+/CD25+ regulatory T-cells (T(reg)). In this study, FOXP3 protein expression has been analysed using a new anti-FOXP3 monoclonal antibody in 172 paraffin-embedded lymphoma samples. FOXP3 expression in tumour cells was confined to adult T-cell leukaemia/lymphoma (ATLL) cases (17/25, 68%), with some variability in the intensity of the staining and the proportion of positive cells. No other lymphoma types studied exhibited FOXP3 expression in the malignant population. The selective expression of FOXP3 by tumour cells in ATLL makes this antibody a potentially useful diagnostic tool.

摘要

FOXP3是一种叉头转录因子家族成员，与T细胞调节、激活及分化有关。FOXP3已被证明是CD4+/CD25+调节性T细胞（T(reg)）发育和功能的主控基因。在本研究中，使用一种新的抗FOXP3单克隆抗体对172例石蜡包埋的淋巴瘤样本进行了FOXP3蛋白表达分析。肿瘤细胞中的FOXP3表达仅限于成人T细胞白血病/淋巴瘤（ATLL）病例（17/25，68%），染色强度和阳性细胞比例存在一定差异。所研究的其他淋巴瘤类型在恶性细胞群体中均未表现出FOXP3表达。ATLL肿瘤细胞对FOXP3的选择性表达使得该抗体成为一种潜在有用的诊断工具。