Follmann D, Elliott P, Suh I, Cutler J
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
J Clin Epidemiol. 1992 Jul;45(7):769-73. doi: 10.1016/0895-4356(92)90054-q.
Overviews of clinical trials are an efficient and important means of summarizing information about a particular scientific area. When the outcome is a continuous variable, both treatment effect and variance estimates are required to construct a confidence interval for the overall treatment effect. Often, only partial information about the variance is provided in the publication of the clinical trial. This paper provides heuristic suggestions for variance imputation based on partial variance information. Both pretest-posttest (parallel groups) and crossover designs are considered. A key idea is to use separate sources of incomplete information to help choose a better variance estimate. The imputation suggestions are illustrated with a data set.
临床试验综述是总结特定科学领域信息的一种有效且重要的手段。当结果是连续变量时，构建总体治疗效果的置信区间需要治疗效果和方差估计值。通常，临床试验出版物中仅提供部分方差信息。本文基于部分方差信息为方差插补提供启发式建议。同时考虑了前后测（平行组）和交叉设计。一个关键思想是利用不完整信息的不同来源来帮助选择更好的方差估计值。通过一个数据集对插补建议进行了说明。
