Bogden J D, Gertner S B, Christakos S, Kemp F W, Yang Z, Katz S R, Chu C
Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103-2714.
J Nutr. 1992 Jul;122(7):1351-60. doi: 10.1093/jn/122.7.1351.
We studied the effects of dietary calcium on kidney, femur, testis, liver, heart and brain concentrations of lead, magnesium, iron, copper, calcium and zinc in rats exposed to lead for 1 y. Renal levels of the 28,000 Da, vitamin D-dependent, calcium-binding protein calbindin-D28K were also measured. Seventy-two weanling male Sprague-Dawley rats were randomly assigned to one of nine treatment groups. Rats were fed diets containing 0.1, 0.5 or 2.5% Ca for 52 wk and were simultaneously given either 0, 50 or 100 mg lead/L in their drinking water. Rats fed the 0.1% Ca diet had organ lead concentrations that were two- to 20-fold greater than the corresponding animals fed 0.5% Ca. Rats fed diets containing 2.5% Ca had the lowest organ lead concentrations. Despite substantial effects of diet Ca on organ lead concentrations, Ca did not significantly influence concentrations of most other divalent metals studied with the exception of kidney calcium and magnesium, testis iron, plasma ionic calcium and magnesium, and several femur metals. Kidney calcium concentrations were lower in rats fed 2.5% Ca diets than in those fed 0.1 or 0.5% Ca diets. For rats not given lead, renal calbindin concentrations were highest in rats fed 0.1% Ca, and lowest in rats fed 2.5% Ca. Lead inhibited an increase in renal calbindin in the rats fed 0.1% Ca, but paradoxically increased renal calbindin levels in animals fed 2.5% Ca.
我们研究了膳食钙对接触铅1年的大鼠肾脏、股骨、睾丸、肝脏、心脏和大脑中铅、镁、铁、铜、钙和锌浓度的影响。同时还测量了肾脏中28,000道尔顿的维生素D依赖性钙结合蛋白钙结合蛋白-D28K的水平。72只断乳雄性Sprague-Dawley大鼠被随机分配到九个处理组之一。大鼠连续52周喂食含0.1%、0.5%或2.5%钙的饮食，同时在饮用水中给予0、50或100毫克/升的铅。喂食0.1%钙饮食的大鼠器官铅浓度比喂食0.5%钙的相应动物高2至20倍。喂食含2.5%钙饮食的大鼠器官铅浓度最低。尽管饮食钙对器官铅浓度有显著影响，但除了肾脏钙和镁、睾丸铁、血浆离子钙和镁以及几种股骨金属外，钙对大多数其他二价金属的浓度没有显著影响。喂食2.5%钙饮食的大鼠肾脏钙浓度低于喂食0.1%或0.5%钙饮食的大鼠。对于未接触铅的大鼠，喂食0.1%钙的大鼠肾脏钙结合蛋白浓度最高，喂食2.5%钙的大鼠最低。铅抑制了喂食0.1%钙的大鼠肾脏钙结合蛋白的增加，但反常地增加了喂食2.5%钙的动物的肾脏钙结合蛋白水平。
