Division of Internal Medicine, Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Department of Public Health, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Int J Environ Res Public Health. 2020 Apr 23;17(8):2909. doi: 10.3390/ijerph17082909.
Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant genes and polymorphisms of metallothioneins (MTs) are associated with different outcomes following lead toxicity. However, no evidence of a relationship between lead neurotoxicity and polymorphisms has previously been presented. In this study, we investigated the relationship between the polymorphisms of , , and genes and lead toxicity following chronic occupational lead exposure. We measured vibration perception thresholds (VPT) and current perception thresholds (CPT) in 181 workers annually for five years. The outcome variables were correlated to the subject's index of long-term lead exposure. Polymorphisms of , , and were defined. The potential confounders, including age, sex, height, smoking, alcohol consumption, and working life span, were also collected and analyzed using linear regression. The regression coefficients of some gene polymorphisms were at least 20 times larger than regression coefficients of time-weighted index of cumulative blood lead (TWICL) measures. All regression coefficients of TWICL increased slightly. rs11640851 (AA/CC) was associated with a statistically significant difference in all neurological outcomes except hand and foot VPT. rs8052394 was associated with statistically significant differences in hand and foot CPT 2000 Hz. In rs10636, those with the C allele showed a greater effect on hand CPT than those with the G allele. Among the gene polymorphisms, the Apa rs7975232 (CC/AA) single nucleotide polymorphism was associated with the greatest difference in hand CPT. rs28366003 appeared to have a neural protective effect, whereas Apa (rs7975232) of and rs10636 increased the neurotoxicity as measured by CPT in the hands. rs8052394 had a protective effect on large myelinated nerves. rs11640851 was associated with susceptibility to neurotoxicity.
慢性暴露于铅对人体周围感觉系统具有神经毒性。金属硫蛋白（MTs）的变体基因和多态性与铅毒性后的不同结果有关。然而，以前没有提出铅神经毒性与多态性之间存在关系的证据。在这项研究中，我们调查了慢性职业性铅暴露后基因、和多态性与铅毒性之间的关系。我们每年对 181 名工人进行振动感觉阈值（VPT）和电流感觉阈值（CPT）测量，为期五年。将结果变量与受试者的长期铅暴露指数相关联。定义了、和基因的多态性。还收集并分析了潜在的混杂因素，包括年龄、性别、身高、吸烟、饮酒和工作寿命，使用线性回归。一些基因多态性的回归系数至少是时间加权累积血铅指数（TWICL）测量值的 20 倍。TWICL 的所有回归系数都略有增加。rs11640851（AA/CC）与所有神经学结果（除了手和脚 VPT）都有统计学显著差异。rs8052394与手和脚 CPT2000Hz 有统计学显著差异。在 rs10636 中，与 C 等位基因相比，携带 C 等位基因的人对手 CPT 的影响更大。在基因多态性中，Apa rs7975232（CC/AA）单核苷酸多态性与手 CPT 的差异最大。rs28366003 似乎具有神经保护作用，而 Apa（rs7975232）和 rs10636 增加了 CPT 对手的神经毒性。rs8052394 对大髓鞘神经有保护作用。rs11640851 与易感性神经毒性有关。
