一名非霍奇金淋巴瘤患者在接受R-CHOP方案及聚乙二醇化非格司亭治疗后发生机化性细支气管炎伴机化性肺炎。

Bronchiolitis obliterans organizing pneumonia in a patient with non-Hodgkin's lymphoma following R-CHOP and pegylated filgrastim.

作者信息

Macartney C, Burke E, Elborn S, Magee N, Noone P, Gleadhill I, Allen D, Kettle P, Drake M

机构信息

Department of Haematology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.

出版信息

Leuk Lymphoma. 2005 Oct;46(10):1523-6. doi: 10.1080/10428190500144615.

DOI:10.1080/10428190500144615

PMID:16194900

Abstract

Bronchiolitis obliterans organizing pneumonia (BOOP) presents with fever, dyspnoea, pleuritic chest pain and hypoxia. The diagnosis can be made from radiological appearances on chest radiograph and CT scan correlated with histological findings following biopsy. We present a 52-year-old gentleman undergoing treatment for high grade non-Hodgkin's lymphoma who developed respiratory symptoms during chemotherapy. BOOP was diagnosed and he responded well to oral prednisolone. The cause of BOOP is often not certain. However, in this case we suspect pegylated filgrastim or rituximab as possible agents.

摘要

闭塞性细支气管炎伴机化性肺炎（BOOP）表现为发热、呼吸困难、胸膜炎性胸痛和低氧血症。根据胸部X线片和CT扫描的影像学表现，并与活检后的组织学结果相关联，可作出诊断。我们报告一位52岁正在接受高级别非霍奇金淋巴瘤治疗的男性患者，他在化疗期间出现了呼吸道症状。诊断为BOOP，口服泼尼松龙后反应良好。BOOP的病因通常不确定。然而，在这个病例中，我们怀疑聚乙二醇化非格司亭或利妥昔单抗可能是病因。