Ayyad Mohammed, Azar Jehad, Albandak Maram, Sharabati Haneen, Salim Hamza, Jaber Yasmin, Al-Tawil Mohammed
Internal Medicine, Al-Quds University, Jerusalem, PSE.
Respiratory Institute, Cleveland Clinic, Cleveland, USA.
Cureus. 2023 Feb 9;15(2):e34798. doi: 10.7759/cureus.34798. eCollection 2023 Feb.
We present a case of rituximab-induced organizing pneumonia (OP) along with bronchiectasis and pulmonary fibrosis, in a patient with a history of granulomatosis with polyangiitis (GPA), on long-term maintenance therapy with rituximab. T-cell dysregulation and B-cell depletion associated with the chronic use of rituximab often lead to a profound immunosuppressed state with hypogammaglobulinemia and unbalanced T-cell response. This acquired immunodeficient state with severe immune dysregulation predisposed this patient to recurrent pulmonary infection and ultimately led to bronchiectasis and pulmonary fibrosis.
我们报告了一例在接受利妥昔单抗长期维持治疗的肉芽肿性多血管炎（GPA）患者中，利妥昔单抗诱发机化性肺炎（OP）并伴有支气管扩张和肺纤维化的病例。长期使用利妥昔单抗导致的T细胞失调和B细胞耗竭常导致严重免疫抑制状态，伴有低丙种球蛋白血症和T细胞反应失衡。这种伴有严重免疫失调的获得性免疫缺陷状态使该患者易反复发生肺部感染，并最终导致支气管扩张和肺纤维化。
