Hoffman Robert M
AntiCancer Inc. and Department of Surgery, University of California, San Diego, 7917 Ostrow Street, San Diego, California 92111, USA.
Nat Rev Cancer. 2005 Oct;5(10):796-806. doi: 10.1038/nrc1717.
Naturally fluorescent proteins have revolutionized biology by enabling what was formerly invisible to be seen clearly. These proteins have allowed us to visualize, in real time, important aspects of cancer in living animals, including tumour cell mobility, invasion, metastasis and angiogenesis. These multicoloured proteins have allowed the colour-coding of cancer cells growing in vivo and enabled the distinction of host from tumour with single-cell resolution. Visualization of many aspects of cancer initiation and progression in vivo should be possible with fluorescent proteins.
天然荧光蛋白使以前不可见的东西能够被清晰地看到，从而给生物学带来了革命性的变化。这些蛋白让我们能够实时观察活体动物体内癌症的重要方面，包括肿瘤细胞的移动、侵袭、转移和血管生成。这些多色蛋白能够对体内生长的癌细胞进行颜色编码，并能以单细胞分辨率区分宿主细胞和肿瘤细胞。利用荧光蛋白应该能够在体内观察癌症起始和进展的许多方面。
