Hamm R J, Dixon C E, Gbadebo D M, Singha A K, Jenkins L W, Lyeth B G, Hayes R L
Department of Psychology, Virginia Commonwealth University, Richmond.
J Neurotrauma. 1992 Spring;9(1):11-20. doi: 10.1089/neu.1992.9.11.
Traumatic brain injury produces significant cognitive deficits in humans. This experiment used a controlled cortical impact model of experimental brain injury to examine the effects of brain injury on spatial learning and memory using the Morris water maze task. Rats (n = 8) were injured at a moderate level of cortical impact injury (6 m/sec, 1.5-2.0 mm deformation). Eight additional rats served as a sham-injured control group. Morris water maze performance was assessed on days 11-15 and 30-34 following injury. Results revealed that brain-injured rats exhibited significant deficits (p less than 0.05) in maze performance at both testing intervals. Since the Morris water maze task is particularly sensitive to hippocampal dysfunction, the results of the present experiment support the hypothesis that the hippocampus is preferentially vulnerable to damage following traumatic brain injury. These results demonstrate that controlled cortical impact brain injury produces enduring cognitive deficits analogous to those observed after human brain injury.
创伤性脑损伤会给人类带来显著的认知缺陷。本实验采用实验性脑损伤的控制性皮质撞击模型，利用莫里斯水迷宫任务来研究脑损伤对空间学习和记忆的影响。大鼠（n = 8）接受中等程度的皮质撞击损伤（6米/秒，1.5 - 2.0毫米变形）。另外8只大鼠作为假损伤对照组。在损伤后的第11 - 15天和第30 - 34天评估莫里斯水迷宫表现。结果显示，在两个测试时间段，脑损伤大鼠在迷宫表现上均出现显著缺陷（p小于0.05）。由于莫里斯水迷宫任务对海马功能障碍特别敏感，本实验结果支持以下假说：创伤性脑损伤后，海马特别容易受到损伤。这些结果表明，控制性皮质撞击脑损伤会产生类似于人类脑损伤后观察到的持久认知缺陷。
