Chen C M, Hsu Y H
Department of Pediatrics, Tzu-Chi Buddhist General Hospital, Hualien, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1992 May;8(5):280-4.
Neonatal lupus erythematosus is a syndrome characterized by congenital heart block and/or cutaneous lupus erythematosus in the presence of maternal autoantibodies. We report a female newborn with cutaneous lesions of the neonatal lupus erythematosus born to a clinically asymptomatic mother. She presented with erythematous maculopapules on the face, neck and upper trunk at birth. Complete blood cell count showed leukopenia and thrombocytopenia. Antinuclear antibodies, anti-Ro/SSA and anti-La/SSB antibodies were positive in the mother and infant. The skin lesions became annular, erythematous and slightly scaling three weeks later. A skin biopsy performed at seven weeks of age showed edema of the dermis and perivascular mononuclear cell infiltration. Immunofluorescent studies showed immune complex deposition of IgG an IgM in the basal zone of epidermis. She received supportive treatment and sun avoidance. Hematologic abnormalities recovered by nine weeks of age. Skin lesions faded gradually during the following four months, leaving residual hypopigmentation and telangiectasia.
新生儿红斑狼疮是一种综合征，其特征为在母亲自身抗体存在的情况下出现先天性心脏传导阻滞和/或皮肤红斑狼疮。我们报告了一名患有新生儿红斑狼疮皮肤病变的女婴，其母亲临床无症状。她出生时面部、颈部和上躯干出现红斑性斑丘疹。全血细胞计数显示白细胞减少和血小板减少。母亲和婴儿的抗核抗体、抗Ro/SSA和抗La/SSB抗体均为阳性。三周后，皮肤病变变为环形、红斑性且有轻微鳞屑。在7周龄时进行的皮肤活检显示真皮水肿和血管周围单核细胞浸润。免疫荧光研究显示IgG和IgM免疫复合物沉积于表皮基底层。她接受了支持性治疗并避免日晒。血液学异常在9周龄时恢复。在接下来的四个月中，皮肤病变逐渐消退，留下残余色素减退和毛细血管扩张。
