Kohge N, Fukuda R
Second Department of Internal Medicine, Shimane Medical University, Izumo, Japan.
Nihon Shokakibyo Gakkai Zasshi. 1992 May;89(5):1242-51.
In order to investigate the hypothesis that viral hepatitis is a host immune response against viral protein presented on hepatocytes, we attempted to cause hepatitis in DHBV carrier ducks by immunization with DHBV protein. While ducks injected with Freund Complete Adjuvant (FCA) showed only weak hepatitis, those immunized with DHBV particle protein showed severe hepatitis. This same procedure could not cause significant inflammation in the liver of ducks without DHBV infection. The severity of hepatitis was well associated with the frequency of the immunization. However, the degree of hepatitis activity was different among same times immunized ducks. Occurrence of hepatitis assumed to have close association with host immune response against viral protein.
为了研究病毒性肝炎是宿主针对肝细胞上呈现的病毒蛋白的免疫反应这一假说，我们尝试通过用鸭乙肝病毒（DHBV）蛋白免疫DHBV携带鸭来引发肝炎。虽然注射弗氏完全佐剂（FCA）的鸭仅表现出轻微肝炎，但用DHBV颗粒蛋白免疫的鸭则表现出严重肝炎。相同的程序在未感染DHBV的鸭肝脏中不会引起明显炎症。肝炎的严重程度与免疫频率密切相关。然而，在相同时间免疫的鸭中，肝炎活动程度有所不同。肝炎的发生被认为与宿主针对病毒蛋白的免疫反应密切相关。
