Christodoulakos George E, Lambrinoudaki Irene V, Vourtsi Athina D, Vlachou Sofia, Creatsa Maria, Panoulis Konstantinos P C, Botsis Dimitrios
2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, 27, Themistokleous Street, Dionysos, GR-14578 Athens, Greece.
Maturitas. 2006 Apr 20;54(1):78-85. doi: 10.1016/j.maturitas.2005.08.012. Epub 2005 Sep 29.
To evaluate the effect of two standard and one low dose continuous hormone therapy regimens on mammography.
One hundred and thirty-two non-hysterectomized postmenopausal women were randomly allocated either to conjugated equine estrogens 0.625 mg plus medroxyprogesterone acetate 5 mg (CEE/MPA, n=38), 17beta-estradiol 2 mg plus norethisterone acetate 1 mg (E2/NETA, n=44) or 17beta-estradiol 1 mg plus norethisterone acetate 0.5 mg (low E2/NETA, n=50). Treatment was continuous and the study period lasted 12 months. Main outcome measures were the changes according to Wolfe classification between baseline and 12-month mammograms.
Five (13.2%) women in the CEE/MPA group showed an increase in breast density. Fourteen (31.8%) women on E2/NETA and 6 (12.2%) on low E2/NETA treatment revealed an increase in breast density. No woman exhibited an involution of fibroglandular tissue.
Different hormone therapy regimens have a variable impact on breast density probably depending on the steroid used. Low dose hormone therapy associates with significantly lesser increase in breast density.
评估两种标准剂量和一种低剂量连续激素治疗方案对乳房X光检查的影响。
132名未行子宫切除术的绝经后女性被随机分配至共轭马雌激素0.625毫克加醋酸甲羟孕酮5毫克组（CEE/MPA，n = 38）、17β-雌二醇2毫克加醋酸炔诺酮1毫克组（E2/NETA，n = 44）或17β-雌二醇1毫克加醋酸炔诺酮0.5毫克组（低剂量E2/NETA，n = 50）。治疗为连续性，研究期持续12个月。主要结局指标是根据沃尔夫分类法，比较基线和12个月乳房X光片的变化。
CEE/MPA组中有5名（13.2%）女性乳房密度增加。E2/NETA组中有14名（31.8%）女性和低剂量E2/NETA组中有6名（12.2%）女性乳房密度增加。没有女性出现纤维腺组织退化。
不同的激素治疗方案对乳房密度有不同影响，可能取决于所使用的类固醇。低剂量激素治疗与乳房密度增加显著较少相关。
