空气污染与英国生物库中老年后乳腺癌风险的关联。
Association of air pollution with postmenopausal breast cancer risk in UK Biobank.
机构信息
Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA.
Department of Surgery, University of Vermont, Burlington, VT, USA.
出版信息
Breast Cancer Res. 2023 Jul 13;25(1):83. doi: 10.1186/s13058-023-01681-w.
BACKGROUND
We investigated the association of several air pollution measures with postmenopausal breast cancer (BCa) risk.
METHODS
This study included 155,235 postmenopausal women (of which 6146 with BCa) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Health Service Central Registers. Annual exposure averages were available from 2005, 2006, 2007, and 2010 for NO, from 2007 and 2010 for PM, and from 2010 for PM, NO, PM and PM absorbance. Information on BCa risk factors was collected at baseline. Cox proportional hazards regression was used to evaluate the associations of year-specific and cumulative average exposures with BCa risk, overall and with 2-year exposure lag, while adjusting for BCa risk factors.
RESULTS
PM in 2007 and cumulative average PM were positively associated with BCa risk (2007 PM: Hazard ratio [HR] per 10 µg/m = 1.18, 95% CI 1.08, 1.29; cumulative average PM: HR per 10 µg/m = 1.99, 95% CI 1.75, 2.27). Compared to women with low exposure, women with higher 2007 PM and cumulative average PM had greater BCa risk (4th vs. 1st quartile HR = 1.15, 95% CI 1.07, 1.24, p-trend = 0.001 and HR = 1.35, 95% CI 1.25, 1.44, p-trend < 0.0001, respectively). No significant associations were found for any other exposure measures. In the analysis with 2-year exposure lag, both 2007 PM 10 and cumulative average PM10 were positively associated with BCa risk (4th vs. 1st quartile HR = 1.19, 95% CI 1.10, 1.28 and HR = 1.29, 95% CI 1.19, 1.39, respectively).
CONCLUSION
Our findings suggest a positive association of 2007 PM and cumulative average PM with postmenopausal BCa risk.
背景
我们研究了几种空气污染指标与绝经后乳腺癌（BCa）风险之间的关联。
方法
这项研究纳入了英国生物库的 155235 名绝经后女性（其中 6146 名患有 BCa）。癌症诊断通过与英国国家卫生服务中心登记册的链接确定。2005 年、2006 年、2007 年和 2010 年可获得每年的 NO 暴露平均值，2007 年和 2010 年可获得 PM 暴露平均值，2010 年可获得 PM、NO、PM 和 PM 吸光率暴露平均值。基线时收集了 BCa 风险因素信息。使用 Cox 比例风险回归评估了特定年份和累积平均暴露与 BCa 风险的关系，包括整体风险和 2 年暴露滞后风险，并对 BCa 风险因素进行了调整。
结果
2007 年 PM 和累积平均 PM 与 BCa 风险呈正相关（2007 年 PM：每 10μg/m 的危害比 [HR]为 1.18，95%置信区间 [CI]为 1.08，1.29；累积平均 PM：每 10μg/m 的 HR 为 1.99，95%CI 为 1.75，2.27）。与低暴露组相比，高 2007 年 PM 和累积平均 PM 暴露组的 BCa 风险更高（第 4 四分位与第 1 四分位 HR 分别为 1.15，95%CI 为 1.07，1.24，p 趋势=0.001 和 HR 分别为 1.35，95%CI 为 1.25，1.44，p 趋势<0.0001）。其他暴露指标均未发现显著关联。在 2 年暴露滞后分析中，2007 年 PM10 和累积平均 PM10 均与 BCa 风险呈正相关（第 4 四分位与第 1 四分位 HR 分别为 1.19，95%CI 为 1.10，1.28 和 HR 分别为 1.29，95%CI 为 1.19，1.39）。
结论
我们的研究结果表明，2007 年 PM 和累积平均 PM 与绝经后 BCa 风险呈正相关。
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