Gunduz-Bruce Handan, McMeniman Marjorie, Robinson Delbert G, Woerner Margaret G, Kane John M, Schooler Nina R, Lieberman Jeffrey A
VA Medical Center, Psychiatry Service 118A, 950 Campbell Ave., West Haven, CT 06516, USA.
Am J Psychiatry. 2005 Oct;162(10):1966-9. doi: 10.1176/appi.ajp.162.10.1966.
Duration of untreated psychosis is associated with time to treatment response among patients with schizophrenia. However, individual psychotic symptoms have not been investigated in this context. The authors examined the relationship between duration of untreated psychosis and time to response for hallucinations and delusions.
Data were available for 118 patients with first-episode schizophrenia in a longitudinal treatment study. Patients received open-label treatment with conventional antipsychotics and were followed for up to 5 years. Duration of untreated psychosis was correlated with time to response for delusions and hallucinations, and predictors of time to response were examined.
Time to response for delusions was significantly longer than that for hallucinations. Duration of untreated psychosis was significantly correlated with time to response for delusions but not for hallucinations. In regression analyses, duration of untreated psychosis was the only predictor for time to response for delusions; it was not a predictor for hallucinations.
The results suggest that duration of untreated psychosis may be specifically associated with time to response for delusions. This association may have clinical implications.
未治疗精神病的持续时间与精神分裂症患者的治疗反应时间相关。然而，尚未在此背景下对个体精神病症状进行研究。作者研究了未治疗精神病的持续时间与幻觉和妄想的反应时间之间的关系。
在一项纵向治疗研究中，有118例首发精神分裂症患者的数据可用。患者接受传统抗精神病药物的开放标签治疗，并随访长达5年。未治疗精神病的持续时间与妄想和幻觉的反应时间相关，并对反应时间的预测因素进行了研究。
妄想的反应时间明显长于幻觉。未治疗精神病的持续时间与妄想的反应时间显著相关，但与幻觉无关。在回归分析中，未治疗精神病的持续时间是妄想反应时间的唯一预测因素；它不是幻觉的预测因素。
结果表明，未治疗精神病的持续时间可能与妄想的反应时间特别相关。这种关联可能具有临床意义。
