Clark Luke, Sarna Antonina, Goodwin Guy M
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, U.K.
Am J Psychiatry. 2005 Oct;162(10):1980-2. doi: 10.1176/appi.ajp.162.10.1980.
The authors' goal was to characterize cognitive flexibility and verbal learning in relatives of patients with bipolar disorder and in euthymic patients with recurrent major depression.
The intradimensional/extradimensional shift task and California Verbal Learning Test were administered to 27 first-degree relatives of probands with bipolar I disorder, 15 euthymic outpatients with recurrent unipolar depression, and 47 healthy comparison subjects.
The relatives of patients with bipolar I disorder and the euthymic patients with unipolar depression were more likely to fail the intradimensional/extradimensional shift task than the healthy comparison subjects. The impairments at the extradimensional shift stage were pronounced. Verbal learning, delayed recall, and recognition were unimpaired in all groups.
Attentional set shifting may represent an endophenotype in mood disorder, related to underlying vulnerability rather than the actual disease phenotype.
作者的目标是对双相情感障碍患者的亲属以及缓解期复发性重度抑郁症患者的认知灵活性和言语学习能力进行特征描述。
对27名双相I型障碍先证者的一级亲属、15名缓解期复发性单相抑郁症门诊患者以及47名健康对照者进行维度内/维度间转换任务和加利福尼亚言语学习测验。
与健康对照者相比，双相I型障碍患者的亲属和缓解期单相抑郁症患者更有可能在维度内/维度间转换任务中失败。维度间转换阶段的损害较为明显。所有组的言语学习、延迟回忆和识别能力均未受损。
注意力定势转换可能代表了情绪障碍中的一种内表型，与潜在易感性而非实际疾病表型相关。
