Simonetti Alessio, Kurian Sherin, Bernardi Evelina, Restaino Antonio, Bardi Francesca, Calderoni Claudia, Sani Gabriele, Soares Jair C, Saxena Kirti
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Section of Psychiatry, Department of Neuroscience, Head-Neck and Chest, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Brain Sci. 2025 Apr 10;15(4):390. doi: 10.3390/brainsci15040390.
Bipolar disorder (BD) and borderline personality disorder (BPD) share common cognitive impairments. These deficits are also shared by bipolar offspring (BD-OFF). Nevertheless, little is known regarding the association between cognitive impairments and BPD features in youth with BD and BD-OFF. This study aimed to investigate the association between BPD features and cognitive impairments in youth with BD and BD-OFF. Thirty-nine participants (7-17 years) with BD, 18 BD-OFF, and 50 healthy controls (HCs) were recruited. BPD features were assessed using the Borderline Personality Features Scale for Children (BPFS-C). Deficits in executive functions and affective processing were assessed using tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), namely, the Cambridge gambling task (CGT), the stockings of Cambridge (SOC), and the Affective Go/No-Go (AGN) and rapid visual processing (RVP) tasks. Between-group differences were analyzed through ANOVAs. Relationships between the BPFS-C and cognitive tasks were examined using multiple linear regressions in youth with BD and BD-OFF. Youth with BD and BD-OFF showed higher scores on the BPFS-C. Youth with BD had increased deficits in the CGT and SOC compared to HCs. In both youth with BD and BD-OFF, BPD features were associated with increased deficits in the CGT, and a bias toward positive emotions in the AGN task. In youth with BD and BD-OFF, clinical and cognitive assessments for BPD features are of relevance as they have the potential to inform targeted interventions.
双相情感障碍（BD）和边缘型人格障碍（BPD）存在共同的认知障碍。双相情感障碍患者的后代（BD - OFF）也有这些缺陷。然而，对于双相情感障碍患者及双相情感障碍患者的后代中，认知障碍与边缘型人格障碍特征之间的关联却知之甚少。本研究旨在调查双相情感障碍患者及双相情感障碍患者的后代中边缘型人格障碍特征与认知障碍之间的关联。招募了39名双相情感障碍患者（7 - 17岁）、18名双相情感障碍患者的后代以及50名健康对照者（HCs）。使用儿童边缘型人格特征量表（BPFS - C）评估边缘型人格障碍特征。使用剑桥神经心理测试自动成套测验（CANTAB）中的任务评估执行功能和情感处理缺陷，即剑桥赌博任务（CGT）、剑桥长袜任务（SOC）、情感Go/No - Go任务（AGN）和快速视觉处理任务（RVP）。通过方差分析（ANOVA）分析组间差异。在双相情感障碍患者及双相情感障碍患者的后代中，使用多元线性回归检验BPFS - C与认知任务之间的关系。双相情感障碍患者及双相情感障碍患者的后代在BPFS - C上得分更高。与健康对照者相比，双相情感障碍患者在CGT和SOC上的缺陷增加。在双相情感障碍患者及双相情感障碍患者的后代中，边缘型人格障碍特征都与CGT中的缺陷增加以及AGN任务中对积极情绪的偏向有关。对于双相情感障碍患者及双相情感障碍患者的后代，边缘型人格障碍特征的临床和认知评估具有重要意义，因为它们有可能为有针对性的干预提供信息。
