Abrosimov Aleksandr Yu, LiVolsi Virginia A
Department of Pathology, Medical Radiological Research Center, Russian Academy of Medical Sciences, Oblinsk, Russia.
Endocr Pathol. 2005 Summer;16(2):139-43. doi: 10.1385/ep:16:2:139.
Spindle epithelial tumor with thymus-like differentiation (SETTLE) is an extremely rare type of thyroid tumor. It has been reported only 20 times in the English literature. This tumor occurs predominantly in young patients and has a protracted clinical course despite the occurrence of metastases. In the recent literature SETTLE has been considered to be a tumor of low malignant potential with distant metastases developing some years after diagnosis. Herein we report a case of SETTLE in a 22-yr-old man in which a lymph node metastasis developed soon after the primary tumor manifestation. Histological examination of the tumor showed the predominantly monophasic variant of SETTLE. The primary and metastatic lesions were highly cellular tumors composed of sheets of spindle cells that were positive for pan-cytokeratin and vimentin and negative for thyroglobulin, calcitonin, and S-100 protein.
伴胸腺样分化的梭形上皮肿瘤（SETTLE）是一种极其罕见的甲状腺肿瘤。英文文献中仅报道过20例。该肿瘤主要发生于年轻患者，尽管会发生转移，但临床病程迁延。在最近的文献中，SETTLE被认为是一种低恶性潜能肿瘤，远处转移在诊断后数年才出现。在此，我们报告一例22岁男性的SETTLE病例，其在原发性肿瘤出现后不久即发生了淋巴结转移。肿瘤的组织学检查显示为SETTLE的主要单相变异型。原发性和转移性病变均为高细胞性肿瘤，由成片的梭形细胞组成，这些细胞全细胞角蛋白和波形蛋白呈阳性，而甲状腺球蛋白、降钙素和S-100蛋白呈阴性。
