Bouchier-Hayes Lisa, Lartigue Lydia, Newmeyer Donald D
La Jolla Institute for Allergy and Immunology, Department of Cellular Immunology, San Diego, California 92121, USA.
J Clin Invest. 2005 Oct;115(10):2640-7. doi: 10.1172/JCI26274.
Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.
细胞凋亡或坏死引起的细胞死亡在疾病的病因学和治疗中往往具有重要意义。由于线粒体在细胞死亡途径中发挥着重要作用,这些细胞器可能是治疗干预的主要靶点。在此,我们将讨论线粒体参与细胞死亡过程的机制,并概述一些以各种方式靶向线粒体的药理学方法。