Kim Jeong Kon, Hong Seong Sook, Choi Young Jun, Park Seong Ho, Ahn Hanjong, Kim Choung-Soo, Cho Kyoung-Sik
Department of Radiology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
J Magn Reson Imaging. 2005 Nov;22(5):639-46. doi: 10.1002/jmri.20431.
To evaluate the usefulness of the wash-in rate based on dynamic contrast-enhanced (DCE) MRI for the detection and localization of prostate cancer.
In 53 patients, the wash-in rate was measured in the cancer area and in three normal areas (the peripheral zone, inner portion of the transitional zone, and outer portion of the transitional zone). On the basis of these data, parametric imaging was generated and then its accuracy for cancer detection and location was evaluated compared to that of T2-weighted imaging without the use of an endorectal coil. For that purpose the entire prostate was divided into 18 segments.
The wash-in rate value was greater in cancer tissue (9.2/second) than in three normal tissues (3.3/second, 6.7/second, and 3.2/second, respectively; P<0.001). The sensitivity and specificity were greater on parametric imaging of the wash-in rate compared to T2-weighted imaging in the entire prostate (96% and 82% vs. 65% and 60%, respectively) and the peripheral zone (96% and 97% vs. 75% and 53%; P<0.05). In the transitional zone, the sensitivity was greater on parametric imaging (96%) than on T2-weighted imaging (45%; P=0.016), but the specificity was similar (51% vs. 73%; P=0.102).
The wash-in rate based on DCE-MRI is a useful parameter for prostate cancer detection and localization.
评估基于动态对比增强（DCE）MRI的流入率在前列腺癌检测和定位中的作用。
对53例患者，在癌灶区域及三个正常区域（外周带、移行带内侧和移行带外侧）测量流入率。基于这些数据生成参数成像，然后将其与未使用直肠内线圈的T2加权成像相比，评估其在癌症检测和定位方面的准确性。为此，将整个前列腺分为18个节段。
癌组织中的流入率值（9.2/秒）高于三个正常组织（分别为3.3/秒、6.7/秒和3.2/秒；P<0.001）。与整个前列腺（分别为96%和82%，对比65%和60%）及外周带（96%和97%，对比75%和53%；P<0.05）的T2加权成像相比，流入率参数成像的敏感性和特异性更高。在移行带，参数成像的敏感性（96%）高于T2加权成像（45%；P=0.016），但特异性相似（分别为51%和73%；P=0.102）。
基于DCE-MRI的流入率是前列腺癌检测和定位的一个有用参数。
