[112例成人急性白血病患者的免疫学分类]
[Immunological classification of 112 adult acute leukemia patients].
作者信息
Dai H
机构信息
Anhui Provincial Hospital, Hefei 230001, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2001 Dec;22(12):633-5.
OBJECTIVE
To explore the criteria and significance of immunological classification in adult acute leukemias.
METHODS
One or two color monoclonal antibodies directly labeled with immunofluorescence were used to analyse the surface and cytoplasma antigens by flow cytometry, and an antibody integral system was developed for the immunologic classification.
RESULTS
One hundred and twelve adult acute leukemia cases were detected. (1) The undifferentiated phenotype account for 0.9%, simple 51.8%, variant 38.4% and mixed lineage 8.9%. (2) The abnormal expressions of antigen in variant and mixed lineage phenotype were CD7, CD33, CD10, CD13, CD19 and CD20, by order of decreased level.
CONCLUSION
The strict, numerical diagnostic criteria was very convenient and useful for immunophenotyping of adult acute leukemia.
目的
探讨成人急性白血病免疫学分型的标准及意义。
方法
采用直接免疫荧光标记的一至双色单克隆抗体，通过流式细胞术分析表面及胞浆抗原，并建立抗体积分系统进行免疫学分型。
结果
检测112例成人急性白血病病例。（1）未分化型占0.9%，单纯型占51.8%，变异型占38.4%，混合谱系型占8.9%。（2）变异型和混合谱系型表型中抗原异常表达依次为CD7、CD33、CD10、CD13、CD19和CD20，按水平递减顺序排列。
结论
严格的数字诊断标准对成人急性白血病免疫表型分析非常方便且有用。
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