Kanazawa Hiroshi, Eguchi Yohsuke, Nomura Naho, Yoshikawa Junichi
Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Ann Allergy Asthma Immunol. 2005 Sep;95(3):266-71. doi: 10.1016/S1081-1206(10)61224-0.
We previously found that vascular endothelial growth factor (VEGF) levels in induced sputum samples are increased in patients with classic asthma and are associated with the degree of airflow obstruction and airway microvascular permeability.
To examine VEGF levels and the degree of airway microvascular permeability in patients with cough variant asthma (CVA).
Levels of VEGF in induced sputum samples and airway microvascular permeability were examined in 12 controls, 16 patients with CVA, and 16 patients with classic asthma. We also evaluated the relationship between VEGF level and the clinical features of these 2 disorders.
Mean (SD) VEGF levels and airway vascular permeability index values were significantly higher in patients with CVA (VEGF: 2,520 [1,050] pg/mL; P < .001; vascular permeability index: 0.017 [0.006]; P = .003) and classic asthma (4,750 [1,260] pg/mL; P < .001; 0.028 [0.009]; P < .001) than in controls (1,420 [1,230] pg/mL; 0.009 [0.003]). Furthermore, these values were significantly higher in patients with classic asthma vs CVA. We also found significant correlations between VEGF level and airway vascular permeability index in patients with CVA (r = 0.60; P = .02) vs classic asthma (r = 0.83; P = .001). Furthermore, VEGF levels were inversely correlated with the degree of airflow obstruction and airway hyperresponsiveness to methacholine in patients with CVA and classic asthma.
Airway microvascular hyperpermeability induced by elevated VEGF levels contributes to abnormal airway function in CVA and classic asthma, and differences in the clinical features of these 2 disorders may depend on airway VEGF levels.
我们之前发现，典型哮喘患者诱导痰样本中的血管内皮生长因子（VEGF）水平升高，且与气流阻塞程度和气道微血管通透性相关。
检测咳嗽变异性哮喘（CVA）患者的VEGF水平及气道微血管通透性程度。
检测了12名对照者、16名CVA患者和16名典型哮喘患者诱导痰样本中的VEGF水平及气道微血管通透性。我们还评估了VEGF水平与这两种疾病临床特征之间的关系。
CVA患者（VEGF：2520[1050]pg/mL；P<.001；血管通透性指数：0.017[0.006]；P=.003）和典型哮喘患者（4750[1260]pg/mL；P<.001；0.028[0.009]；P<.001）的VEGF平均（标准差）水平和气道血管通透性指数值显著高于对照者（1420[1230]pg/mL；0.009[0.003]）。此外，典型哮喘患者的这些值显著高于CVA患者。我们还发现，CVA患者（r=0.60；P=.02）和典型哮喘患者（r=0.83；P=.001）的VEGF水平与气道血管通透性指数之间存在显著相关性。此外，CVA和典型哮喘患者的VEGF水平与气流阻塞程度及对乙酰甲胆碱的气道高反应性呈负相关。
VEGF水平升高所致的气道微血管高通透性导致CVA和典型哮喘患者气道功能异常，这两种疾病临床特征的差异可能取决于气道VEGF水平。
