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气道循环会影响哮喘中的气流阻塞吗？

Does the airway circulation influence airflow obstruction in asthma?

作者信息

Wanner Adam

机构信息

Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA

出版信息

BMJ Open Respir Res. 2025 Apr 17;12(1):e002575. doi: 10.1136/bmjresp-2024-002575.

DOI:10.1136/bmjresp-2024-002575
PMID:40246572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12007055/
Abstract

The airway wall is thickened in asthma and the airway microvasculature participates in the remodelling. It has been assumed but not convincingly demonstrated that the remodelled airway vasculature has a mechanical role in asthma-associated airflow obstruction by contributing to the thickening of the airway wall and narrowing of the airway. This review examines the literature providing information in support of and against this assumption and raises questions about therapeutically targeting the airway circulation directly in patients with asthma.

摘要

哮喘时气道壁增厚，气道微血管参与重塑过程。虽然有人认为重塑的气道血管通过促使气道壁增厚和气道狭窄在哮喘相关气流阻塞中起机械作用，但这一观点尚未得到令人信服的证实。本综述研究了支持和反对这一假设的文献，并提出了关于直接针对哮喘患者气道循环进行治疗的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd1/12007055/ce47a54d9da9/bmjresp-12-1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd1/12007055/1e885bf891bd/bmjresp-12-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd1/12007055/b2fe92e21152/bmjresp-12-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd1/12007055/ce47a54d9da9/bmjresp-12-1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd1/12007055/1e885bf891bd/bmjresp-12-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd1/12007055/b2fe92e21152/bmjresp-12-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd1/12007055/ce47a54d9da9/bmjresp-12-1-g003.jpg

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本文引用的文献

1
Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy.近年来血管内皮生长因子受体抑制剂在肿瘤治疗中双重靶向能力的研究进展。
J Hematol Oncol. 2022 Jul 7;15(1):89. doi: 10.1186/s13045-022-01310-7.
2
Cyclo-VEGI inhibits bronchial artery remodeling in a murine model of chronic asthma.环磷酰胺-血管内皮生长抑制因子在慢性哮喘小鼠模型中抑制支气管动脉重塑。
Exp Lung Res. 2021 Dec;47(10):494-506. doi: 10.1080/01902148.2021.2015011. Epub 2021 Dec 10.
3
Airway wall thickness and airflow limitations in asthma assessed in quantitative computed tomography.
定量计算机断层扫描评估哮喘的气道壁厚度和气流受限。
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466619898598. doi: 10.1177/1753466619898598.
4
Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma.致死性哮喘中肺和支气管动脉的结构改变及内皮激活标志物
Allergy Asthma Clin Immunol. 2019 Aug 28;15:50. doi: 10.1186/s13223-019-0363-0. eCollection 2019.
5
Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice.百里醌抑制哮喘小鼠的炎症、新生血管形成和血管重塑。
Int Immunopharmacol. 2016 Sep;38:70-80. doi: 10.1016/j.intimp.2016.05.018. Epub 2016 May 27.
6
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Eur J Pharmacol. 2015 May 5;754:98-104. doi: 10.1016/j.ejphar.2015.02.014. Epub 2015 Feb 20.
7
Acute effect of an inhaled glucocorticosteroid on albuterol-induced bronchodilation in patients with moderately severe asthma.吸入性糖皮质激素对中度重度哮喘患者沙丁胺醇诱导的支气管扩张的急性作用。
Chest. 2015 Apr;147(4):1037-1042. doi: 10.1378/chest.14-1742.
8
Asthma is not only an airway disease, but also a vascular disease.哮喘不仅是一种气道疾病，也是一种血管疾病。
Pharmacol Ther. 2015 Apr;148:17-33. doi: 10.1016/j.pharmthera.2014.11.010. Epub 2014 Nov 20.
9
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Cold Spring Harb Perspect Biol. 2014 Oct 23;7(1):a016345. doi: 10.1101/cshperspect.a016345.
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Pulm Pharmacol Ther. 2014 Dec;29(2):144-55. doi: 10.1016/j.pupt.2014.09.003. Epub 2014 Oct 12.