[鼻息肉中总免疫球蛋白E与嗜酸性粒细胞的相关性研究]
[Study on the association among total immunoglobulin E and eosinophil in nasal polyp].
作者信息
Zhu Shenghua, Luo Xuemei
机构信息
Department of Otolaryngology, Shaoyang Central Hospital, Shaoyang, 422000, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jul;19(13):602-4.
OBJECTIVE
To explore the expression of total immunoglobulin E(IgE) and eosinophil in nasal polyp and their roles in the pathogenesis of nasal polyp.
METHOD
Thirty eight patients with nasal polyp and 15 control cases were chosen. All samples were stained with Chromotrope 2R histochemical and SP immunohistochemical method separately to examine eosinophil and total IgE+ cells in nasal polyp.
RESULT
(1) The level of total IgE and eosinophil in nasal polyp was all significantly higher than that in normal control specimens (P < 0.01). (2) The positive correlation of total IgE and eosinophil was significant (r = 0.843, P < 0.01).
CONCLUSION
Nasal polyp is a disease characterized by eosinophils infiltration. Type I allergic reaction mediated by IgE assemble and activate eosinophils which may play an important role in the infiltration pathogenesis of nasal polyp.
目的
探讨总免疫球蛋白E（IgE）及嗜酸性粒细胞在鼻息肉中的表达及其在鼻息肉发病机制中的作用。
方法
选取38例鼻息肉患者及15例对照病例。所有标本分别采用变色酸2R组织化学染色法和SP免疫组织化学法检测鼻息肉中的嗜酸性粒细胞及总IgE⁺细胞。
结果
（1）鼻息肉中总IgE及嗜酸性粒细胞水平均显著高于正常对照标本（P < 0.01）。（2）总IgE与嗜酸性粒细胞呈显著正相关（r = 0.843，P < 0.01）。
结论
鼻息肉是以嗜酸性粒细胞浸润为特征的疾病。由IgE介导的I型过敏反应募集并激活嗜酸性粒细胞，其可能在鼻息肉浸润发病机制中起重要作用。
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