Department of Biochemistry, Abant Izzet Baysal University, Golkoy, Bolu, Turkey.
Acta Histochem. 2010;112(1):92-5. doi: 10.1016/j.acthis.2008.07.002. Epub 2008 Oct 2.
Matrix metalloproteinases (MMPs) are known to play important roles in the invasion of nasal mucosa by inflammatory cells through degradation of extracellular matrix. Matrix metalloproteinase-9 (MMP-9) is considered to play a role in the pathogenesis of nasal polyp. The aim of the present study was to compare plasma MMP-9 levels of patients with nasal polyp of different etiologic origins, those with allergic nasal polyp (ANP) and non-allergic nasal polyp (NANP). In all, 29 patients (20 NANP and 9 ANP) and 20 healthy subjects were included in this study. Plasma MMP-9 levels were measured using ELISA. Plasma MMP-9 levels were higher (p<0.05) in ANP patients than in NANP patients and controls. In the group with ANP, plasma MMP-9 levels showed a positive correlation (p<0.05) with eosinophil counts. Plasma MMP-9 levels of NANP patients and control groups were similar (p>0.05). Moreover, that the highest levels of MMP-9 were in ANP patients may indicate the usefulness of this parameter in differentiating between the different etiologic origins of nasal polyp. Further studies are required to elaborate on the relationship between MMP-9 levels and allergic reactions.
基质金属蛋白酶（MMPs）被认为在炎症细胞通过降解细胞外基质侵犯鼻黏膜中发挥重要作用。基质金属蛋白酶-9（MMP-9）被认为在鼻息肉的发病机制中起作用。本研究旨在比较不同病因鼻息肉患者、过敏性鼻息肉（ANP）和非过敏性鼻息肉（NANP）患者的血浆 MMP-9 水平。共有 29 名患者（20 名 NANP 和 9 名 ANP）和 20 名健康受试者纳入本研究。使用 ELISA 测定血浆 MMP-9 水平。ANP 患者的血浆 MMP-9 水平高于 NANP 患者和对照组（p<0.05）。在 ANP 组中，血浆 MMP-9 水平与嗜酸性粒细胞计数呈正相关（p<0.05）。NANP 患者和对照组的血浆 MMP-9 水平相似（p>0.05）。此外，ANP 患者 MMP-9 水平最高可能表明该参数在区分鼻息肉的不同病因方面有用。需要进一步研究来阐述 MMP-9 水平与过敏反应之间的关系。
