囊性纤维化患者的β细胞自身抗体与糖尿病家族史
Beta-cell autoantibodies and diabetes mellitus family history in cystic fibrosis.
作者信息
Minicucci Laura, Cotellessa Mario, Pittaluga Livia, Minuto Nicola, d'Annunzio Giuseppe, Avanzini Maria Antonietta, Lorini Renata
机构信息
Department of Pediatrics, IRCCS-G. Gaslini Institute, Genoa, Italy.
出版信息
J Pediatr Endocrinol Metab. 2005 Aug;18(8):755-60. doi: 10.1515/jpem.2005.18.8.755.
OBJECTIVE
To verify whether autoimmunity against beta-cells and family history of type 1 and/or type 2 diabetes mellitus (DM) play a role in the pathogenesis of cystic fibrosis (CF)-related diabetes mellitus (CFRD).
PATIENTS AND METHODS
The prevalence of beta-cell autoantibodies (GADA and IA-2A) was investigated in a group of patients with CF compared with patients with type 1 DM (DM1) and controls. Family history of DM1 and/or DM2 was investigated among patients with CF.
RESULTS
Frequency of beta-cell autoantibodies was significantly lower (p = 0.0001) in patients with CF with CFRD (IA-2A: 0%; GADA 12.5%) than in patients with DM1 (64.1% vs 52.8%, respectively) and it did not differ from the frequency in patients with CF without CFRD. Prevalence of family history for DM1 or DM2 was not significantly higher in CF patients with CFRD than in CF patients without CFRD.
CONCLUSIONS
The investigated factors did not show correlation with the pathogenesis of CFRD.
目的
验证针对β细胞的自身免疫以及1型和/或2型糖尿病（DM）家族史是否在囊性纤维化（CF）相关糖尿病（CFRD）的发病机制中起作用。
患者与方法
在一组CF患者中研究β细胞自身抗体（谷氨酸脱羧酶抗体[GADA]和胰岛抗原2抗体[IA - 2A]）的患病率，并与1型糖尿病（DM1）患者及对照组进行比较。在CF患者中调查DM1和/或DM2的家族史。
结果
患有CFRD的CF患者中β细胞自身抗体的频率（IA - 2A：0%；GADA 12.5%）显著低于DM1患者（分别为64.1%和52.8%）（p = 0.0001），且与无CFRD的CF患者的频率无差异。患有CFRD的CF患者中DM1或DM2家族史的患病率并不显著高于无CFRD的CF患者。
结论
所研究的因素与CFRD的发病机制无相关性。
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