Wu J, Zhou L, Chen H, Mao Y, Zhang F
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhonghua Wai Ke Za Zhi. 2001 Dec;39(12):931-4.
To explore the diagnosis and treatment of paragangliomas in the central nerve system.
17 patients with paragangliomas in the central nerve system over a 20-year period (1976-1999) were analyzed retrospectively. They included 11 patients with glomus jugular tumors, 1 with carotid body tumor, 1 with supersellar paraganglioma, 2 with spinal involvement, and 2 with superficial hemisphere involvement.
Neoplasm was completely resected in 11 patients, subtotally in 3, and partial in 3. The postoperative mortality was 1/17. One patient remained severe disability, yet the others had excellent long-time outcome.
Both the characteristic clinical presentation and neuroradiological manifestation were useful for preoperative diagnosis. Total resection is ideal for paragangliomas. Preoperative embolization should be used routinely to control intraoperative bleeding, and postoperative radiation-therapy would be valuable to control the recurrence of the remaining tumor.
探讨中枢神经系统副神经节瘤的诊断与治疗。
回顾性分析1976年至1999年20年间17例中枢神经系统副神经节瘤患者。其中包括11例颈静脉球瘤患者、1例颈动脉体瘤患者、1例鞍上副神经节瘤患者、2例累及脊髓患者以及2例累及大脑半球浅表部位患者。
11例患者肿瘤完全切除，3例次全切除，3例部分切除。术后死亡率为1/17。1例患者仍有严重残疾，其他患者长期预后良好。
特征性的临床表现和神经影像学表现有助于术前诊断。肿瘤全切除是副神经节瘤的理想治疗方式。术前应常规进行栓塞以控制术中出血，术后放疗对控制残留肿瘤复发有重要价值。
