腹部手术中短期与长期抗菌药物预防：一项多中心开放性随机对照试验
[Short-term versus long-term antimicrobial prophylaxis in abdominal surgery: a multicenter open randomized comparative trial].
作者信息
Yang Z
机构信息
Department of General Surgery, Peking Union Medial College Hospital, Beijing 100730, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2001 Oct;39(10):770-2.
OBJECTIVE
To evaluate the outcome of short-term antimicrobial prophylaxis versus long-term in surgical site infection (SSI).
METHODS
731 patients undergoing abdominal operation from 15 hospitals were randomly divided into 2 groups. 358 patients were enrolled in the short-term group (24 h), and 373 patients in the long-term group (72 h). There was no difference between the 2 groups with regard to age, sex, and types operation. Netilmicin was used alone or in combination with metronidazole.
RESULTS
The rates of SSI in the short-term and long-term groups were 0.84% and 2.68% (P > 0.05), respectively.
CONCLUSIONS
The results demonstrated that the short-term antimicrobial agents prophylaxis is effective in the prevention of post-operative SSI. The long-term one act does not better than the short-term in terms of rationality and pharmacoeconomics.
目的
评估短期与长期抗菌药物预防在手术部位感染（SSI）中的效果。
方法
来自15家医院的731例行腹部手术的患者被随机分为2组。358例患者纳入短期组（24小时），373例患者纳入长期组（72小时）。两组在年龄、性别和手术类型方面无差异。单独使用奈替米星或与甲硝唑联合使用。
结果
短期组和长期组的SSI发生率分别为0.84%和2.68%（P>0.05）。
结论
结果表明，短期抗菌药物预防对预防术后SSI有效。从合理性和药物经济学角度来看，长期预防并不优于短期预防。
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