Yin Wen-xuan, Liu Yu-feng, Zhao Ying, Gao Qing-yu, Wu Jin-guang
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Jun;25(6):930-3.
This is an in vitro model to mimic the conditions present during gallstone formation. Adenosine mono-phosphate (AMP), an important bio-molecule, was chosen. Its effect on the formation of periodic/chaotic patterns in the deoxycholate-CuCl2-gel and deoxycholate-CuCl2-glucose-gel systems were studied. FTIR spectroscopy was used to identify the structure of the precipitates. The results indicate that the patterns formed in the systems with AMP are different. And FTIR spectra show that AMP may also be involved in the coordination sphere of Cu2+ ion. The results are more complicated in the deoxycholate-CuCl2 system containing glucose, suggesting that the nonlinear scientific concept should be considered in understanding gallstone formation.
这是一个用于模拟胆结石形成过程中存在条件的体外模型。选择了重要的生物分子单磷酸腺苷（AMP）。研究了其对脱氧胆酸盐 - CuCl₂ - 凝胶和脱氧胆酸盐 - CuCl₂ - 葡萄糖 - 凝胶体系中周期性/混沌模式形成的影响。使用傅里叶变换红外光谱（FTIR）来鉴定沉淀物的结构。结果表明，含有AMP的体系中形成的模式不同。并且FTIR光谱显示AMP也可能参与Cu²⁺离子的配位球。在含有葡萄糖的脱氧胆酸盐 - CuCl₂体系中结果更为复杂，这表明在理解胆结石形成时应考虑非线性科学概念。
