Adam I, Mirghani O A, Saed O K, Ahmed S M, Mohamadani A A, Ahmed H M, Mackenzie C D, Homeida M M A, Elbashir M I
New Halfa Hospital, New Halfa, Sudan.
East Mediterr Health J. 2004 Jan-Mar;10(1-2):159-66.
A prospective study was carried out in an area of unstable malaria transmission in central Sudan to determine the efficacy and toxicity of quinine in pregnancy. Thirty-three pregnant women with severe Plasmodium falciparum malaria at mean 28.8 weeks gestational age were treated with quinine for 7 days. The mean body temperature on presentation for 3 patients who delivered prematurely was significantly higher than for those who delivered at term (39.2 +/- 0.7 degrees C versus 38.7 +/- 1.3 degrees C). There were no significant difference between the 2 groups in other clinical or biochemical parameters. There were no clinically detectable congenital malformations and no auditory, visual or other neurological deficits in the babies at birth or 6 months later. Quinine may be safe in the treatment of severe falciparum malaria during pregnancy.
在苏丹中部疟疾传播不稳定地区开展了一项前瞻性研究，以确定奎宁在孕期的疗效和毒性。33名平均孕周为28.8周的重度恶性疟原虫疟疾孕妇接受了7天的奎宁治疗。3名早产患者就诊时的平均体温显著高于足月分娩者（39.2±0.7摄氏度对38.7±1.3摄氏度）。两组在其他临床或生化参数方面无显著差异。出生时及6个月后，婴儿均未出现临床可检测到的先天性畸形，也没有听觉、视觉或其他神经功能缺陷。奎宁在孕期治疗重度恶性疟疾可能是安全的。
