Coskun Abdurrahman
Abant Izzet Baysal University, Duzce School of Medicine, Department of Clinical Biochemistry, Duzce, Turkey.
Clin Chem Lab Med. 2005;43(8):880-2. doi: 10.1515/CCLM.2005.148.
In clinical laboratories, patient results can be obtained in two ways: (i) by direct determination of requested tests using various chemical methods, (ii) by calculation of unknown test results, based on relationships between measured tests. The reliability of measured tests can be checked by various quality control rules. However, no test is performed to check the reliability of calculated data. In this study we develop a method using Taylor series expansion and an alternative equation to obtain the standard deviation of calculated laboratory tests and discuss the reliability of calculated data. To obtain reliable test results by calculation instead of being measured by chemical methods, the standard deviation of each measured component of the equation must be thoroughly analyzed and then the standard deviation of the equation must be determined. We conclude that the analytical coefficient of variation of any measured component must be lower so as to obtain an acceptable analytical coefficient of variation for calculated tests. Otherwise we should measure the concentration of requested tests by chemical methods instead of calculation by equation using specified components.
在临床实验室中，可通过两种方式获得患者检测结果：（i）使用各种化学方法直接测定所要求的检测项目；（ii）基于所测检测项目之间的关系计算未知检测结果。所测检测项目的可靠性可通过各种质量控制规则进行检查。然而，并未进行任何检测来检查计算数据的可靠性。在本研究中，我们开发了一种使用泰勒级数展开和替代方程的方法来获得计算得出的实验室检测项目的标准差，并讨论计算数据的可靠性。为了通过计算而非化学方法测量来获得可靠的检测结果，必须对等式中每个测量成分的标准差进行全面分析，然后确定等式的标准差。我们得出结论，任何测量成分的分析变异系数必须更低，以便获得计算检测项目可接受的分析变异系数。否则，我们应该通过化学方法测量所要求检测项目的浓度，而不是使用特定成分通过等式进行计算。
