Yang Guang-Zhi, Li Li, Ding Hua-Ye, Zhou Jin-Song
Department of Pathology, The General Hospital of Beijing Military Command, Beijing 100700, People's Republic of China.
Exp Mol Pathol. 2005 Dec;79(3):214-8. doi: 10.1016/j.yexmp.2005.09.002. Epub 2005 Oct 3.
Cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the synthesis of prostaglandins, has been found to be over-expressed in several human cancers. The aim of the present study was to investigate immunohistochemical expression of COX-2 in esophageal squamous cell carcinoma (SCC) and relationship with clinicopathological parameters and NF-kappaB.
Expression of COX-2 and NF-kappaB was investigated in 69 cases of esophageal SCC by immunohistochemistry and the correlation of COX-2 expression with clinicopathological features and NF-kappaB staining was examined.
Thirty-one esophageal SCC (31/69, 44.9%) had positive expression of COX-2. COX-2 was expressed significantly higher in well-differentiated tumors (16/23, 69.6%) than that in moderate (13/34, 38.2%) and poor (2/12, 16.7%) differentiation (P = 0.034). COX-2 expression was increasingly progressive with the advance of the clinical stages significantly (P = 0.045). The correlation between COX-2 (47/99, 47.5%) and NF-kappaB/p50 (54/99, 54.5%) immunostaining was statistically significant (P = 0.030).
COX-2 is over-expressed in esophageal SCC, especially in a well differentiation, correlated with tumor progression, and possibly regulated by NF-kappaB.
环氧化酶-2（COX-2）是前列腺素合成关键酶的诱导型同工酶，已发现在多种人类癌症中过度表达。本研究旨在探讨COX-2在食管鳞状细胞癌（SCC）中的免疫组化表达及其与临床病理参数和核因子κB（NF-κB）的关系。
采用免疫组化法检测69例食管SCC中COX-2和NF-κB的表达，并分析COX-2表达与临床病理特征及NF-κB染色的相关性。
31例食管SCC（31/69，44.9%）COX-2呈阳性表达。COX-2在高分化肿瘤（16/23，69.6%）中的表达明显高于中分化（13/34，38.2%）和低分化（2/12，16.7%）肿瘤（P = 0.034）。COX-2表达随临床分期进展呈逐渐升高趋势，差异有统计学意义（P = 0.045）。COX-2（47/99，47.5%）与NF-κB/p50（54/99，54.5%）免疫染色的相关性具有统计学意义（P = 0.030）。
COX-2在食管SCC中过度表达，尤其是在高分化肿瘤中，与肿瘤进展相关，可能受NF-κB调控。
