The benefits of the multi-target approach in drug design and discovery.
作者信息
Espinoza-Fonseca L Michel
机构信息
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, 55455, USA.
出版信息
Bioorg Med Chem. 2006 Feb 15;14(4):896-7. doi: 10.1016/j.bmc.2005.09.011. Epub 2005 Oct 3.
PMID:16203151
Abstract
Promiscuous binding has been considered to be a problem in the design and development of new drugs against a given disease. However, promiscuity in molecular recognition is not all bad news, and scientists are currently taking advantage of the emerging 'promiscuous binding' or 'multi-target approach' in medicinal chemistry.
摘要
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