一项基于人群的研究：孕期支气管哮喘与较短孕周之间的关联。
Association between bronchial asthma in pregnancy and shorter gestational age in a population-based study.
作者信息
Acs Nándor, Puhó Erzsébet, Bánhidy Ferenc, Czeizel Andrew E
机构信息
Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary.
出版信息
J Matern Fetal Neonatal Med. 2005 Aug;18(2):107-12. doi: 10.1080/14767050500198337.
OBJECTIVE
To study the association between bronchial asthma during pregnancy and gestational age/birth weight, and also preterm birth and low birth weight.
METHOD
In the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, controls without congenital abnormalities were analysed.
RESULTS
Of 38,151 newborn infants, 757 (2.0%) had mothers with bronchial asthma during pregnancy, 88% were medically recorded prospectively. Mothers with bronchial asthma in pregnancy had 0.6 week shorter gestational age and a higher proportion of preterm births (14.1% vs. 9.1%). These findings were reflected with a lower mean birth weight (3,102 vs. 3,279 gram) and higher proportion of low birth weight newborns (9.0% vs. 5.6%).
CONCLUSION
The old fashioned anti-asthmatic drugs were not able to prevent the bronchial asthma-related preterm birth, thus there is an urgent need to use modern inhaled therapies.
目的
研究孕期支气管哮喘与孕周/出生体重之间的关联，以及早产和低出生体重情况。
方法
在匈牙利先天性异常病例对照监测系统基于人群的1980 - 1996年大数据集中，对无先天性异常的对照组进行分析。
结果
在38151例新生儿中，757例（2.0%）母亲孕期患有支气管哮喘，其中88%有前瞻性医学记录。孕期患支气管哮喘的母亲孕周缩短0.6周，早产比例更高（14.1%对9.1%）。这些结果表现为平均出生体重较低（3102克对3279克）以及低出生体重新生儿比例更高（9.0%对5.6%）。
结论
老式抗哮喘药物无法预防支气管哮喘相关的早产，因此迫切需要使用现代吸入疗法。
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