神经D2转录因子的剂量调节杏仁核发育和情绪学习。
The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning.
作者信息
Lin Chin-Hsing, Hansen Stacey, Wang Zhenshan, Storm Daniel R, Tapscott Stephen J, Olson James M
机构信息
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
出版信息
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14877-82. doi: 10.1073/pnas.0506785102. Epub 2005 Oct 3.
Abstract
The amygdala is centrally involved in formation of emotional memory and response to fear or risk. We have demonstrated that the lateral and basolateral amygdala nuclei fail to form in neuroD2 null mice and neuroD2 heterozygotes have fewer neurons in this region. NeuroD2 heterozygous mice show profound deficits in emotional learning as assessed by fear conditioning. Unconditioned fear was also diminished in neuroD2 heterozygotes compared to wild-type controls. Several key molecular regulators of emotional learning were diminished in the brains of neuroD2 heterozygotes including Ulip1, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, and GABA(A) receptor. Thus, neuroD2 is essential for amygdala development and genes involved in amygdala function are altered in neuroD2-deficient mice.
摘要
杏仁核在情绪记忆的形成以及对恐惧或风险的反应中起着核心作用。我们已经证明，在NeuroD2基因敲除小鼠中，外侧和基底外侧杏仁核核团无法形成，并且NeuroD2杂合子在该区域的神经元数量较少。通过恐惧条件反射评估发现，NeuroD2杂合子小鼠在情绪学习方面存在严重缺陷。与野生型对照相比，NeuroD2杂合子的无条件恐惧也有所减轻。在NeuroD2杂合子的大脑中，包括Ulip1、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体和GABA（A）受体在内的几种情绪学习关键分子调节因子减少。因此，NeuroD2对杏仁核发育至关重要，并且在NeuroD2缺陷小鼠中，参与杏仁核功能的基因发生了改变。
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