四[N-邻苯二甲酰基-(S)-叔亮氨酸根]二铑(II)的实用合成
Practical synthesis of Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate].
作者信息
Tsutsui Hideyuki, Abe Takumi, Nakamura Seiichi, Anada Masahiro, Hashimoto Shunichi
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1366-8. doi: 10.1248/cpb.53.1366.
PMID:16205006
Abstract
An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)(4), a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.
摘要
本文描述了一种高效可靠的制备四[ N-邻苯二甲酰基-(S)-叔亮氨酸]二铑(II)（Rh2(S-PTTL)(4)）的方法，它是一系列对映选择性卡宾转化反应的通用有效催化剂。通过Bose方法对(S)-叔亮氨酸进行N-邻苯二甲酰化，且基本不发生消旋化，是该过程的关键。
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