Downs Jessica A, Côté Jacques
Department of Biochemistry, University of Cambridge, Cambridge, UK.
Cell Cycle. 2005 Oct;4(10):1373-6. doi: 10.4161/cc.4.10.2108. Epub 2005 Oct 17.
Double strand breaks (DSBs) are arguably the most deleterious DNA lesion that a cell can sustain, and defects in the ability to detect and repair these breaks result in increased genomic instability and have been causatively linked to cancer. The repair of DNA DSBs must occur in the context of chromatin, and there is increasing evidence that the modulation of chromatin plays an integral role in the DNA DSB repair process. Here, we summarize a number of key findings, largely from studies performed in budding yeast, highlighting the role of chromatin in DNA DSB responses.
双链断裂（DSBs）可以说是细胞可能遭受的最有害的DNA损伤，检测和修复这些断裂的能力缺陷会导致基因组不稳定性增加，并且与癌症有因果关系。DNA双链断裂的修复必须在染色质的背景下进行，越来越多的证据表明染色质的调节在DNA双链断裂修复过程中起着不可或缺的作用。在这里，我们总结了一些主要来自于对芽殖酵母研究的关键发现，突出了染色质在DNA双链断裂反应中的作用。
