Irving Peter M, Pasi K John, Rampton David S
Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and The London NHS Trust, United Kingdom.
Clin Gastroenterol Hepatol. 2005 Jul;3(7):617-28. doi: 10.1016/s1542-3565(05)00154-0.
Interaction between thrombosis and inflammation is increasingly recognized. With this, interest has arisen in the role of thrombosis in inflammatory conditions, including the inflammatory bowel diseases. Although the association between active inflammatory bowel disease and thromboembolic complications has long been known, there has been a resurgence in research into the role of thrombosis and the hemostatic system in the pathogenesis of both ulcerative colitis and Crohn's disease. Here we review the increased frequency of thromboembolic complications occurring in patients with inflammatory bowel disease; whether thrombosis might play a part in the initiation and maintenance of inflammation in inflammatory bowel disease; abnormalities of the coagulation system found in patients with inflammatory bowel disease; platelet dysfunction in inflammatory bowel disease; the mechanisms by which hemostatic processes might be proinflammatory in inflammatory bowel disease; and how these interactions might impact not only on the prevention of complications, but also on the treatment of the underlying inflammation in inflammatory bowel disease.
血栓形成与炎症之间的相互作用日益受到认可。由此，人们对血栓形成在包括炎症性肠病在内的炎症性疾病中的作用产生了兴趣。尽管活动性炎症性肠病与血栓栓塞并发症之间的关联早已为人所知，但关于血栓形成和止血系统在溃疡性结肠炎和克罗恩病发病机制中的作用的研究再度兴起。在此，我们综述炎症性肠病患者中血栓栓塞并发症发生频率的增加；血栓形成是否可能在炎症性肠病炎症的起始和维持中发挥作用；炎症性肠病患者中发现的凝血系统异常；炎症性肠病中的血小板功能障碍；止血过程在炎症性肠病中可能具有促炎作用的机制；以及这些相互作用如何不仅影响并发症的预防，还影响炎症性肠病潜在炎症的治疗。
