Ritskes-Hoitinga J, Beynen A C
Department of Laboratory Animal Science State University, Utrecht.
Prog Food Nutr Sci. 1992;16(1):85-124.
Nephrocalcinosis is a common disorder in female rats. Various etiological factors are involved in the pathogenesis, e.g. sex, age, genetical and dietary factors. Dietary phosphorus concentration appears to be of crucial importance in the induction of nephrocalcinosis. The pathological changes in calcinotic kidney tissue are described. Possible mechanisms underlying nephrocalcinogenesis are discussed. Phosphorus concentration within the proximal tubule may be the major determinant of nephrocalcinogenesis.
肾钙质沉着症是雌性大鼠常见的病症。发病机制涉及多种病因，如性别、年龄、遗传和饮食因素。饮食中磷的浓度在肾钙质沉着症的诱发中似乎至关重要。描述了钙质沉着性肾组织的病理变化。讨论了肾钙质沉着症发生的可能机制。近端小管内的磷浓度可能是肾钙质沉着症发生的主要决定因素。
