Soeterboek S J, Ritskes-Hoitinga J, Lemmens A G, Beynen A C
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
Lab Anim. 1991 Jul;25(3):258-62. doi: 10.1258/002367791780808301.
The question addressed was whether preestablished phosphorus (P)-induced nephrocalcinosis would regress after dietary P restriction. Female rats were fed purified diets containing either 0.2% (w/w) P (low P) or 0.6% P (high P). After 29 days, the high-P diet had caused massive nephrocalcinosis as demonstrated chemically (by the analysis of calcium in kidney) and histologically (by inspection of kidney sections stained for calcium phosphate deposits). Switching rats from the high P to the low P diet did not result in a decrease in the degree of nephrocalcinosis within 91 days. Thus, P-induced nephrocalcinosis may not regress upon subsequent P restriction. Rats that had been fed either the 0.2 or 0.6% P diet for 56 days were examined clinically with respect to 14 selected variables. None of the variables discriminated between rats with or without nephrocalcinosis. This might imply that P-induced nephrocalcinosis in female rats does not cause significant discomfort.
研究的问题是，预先形成的磷（P）诱导的肾钙质沉着症在饮食磷限制后是否会消退。给雌性大鼠喂食含0.2%（w/w）磷（低磷）或0.6%磷（高磷）的纯化饮食。29天后，高磷饮食导致了大量肾钙质沉着症，这在化学上（通过分析肾脏中的钙）和组织学上（通过检查用磷酸钙沉积染色的肾脏切片）都得到了证实。将大鼠从高磷饮食转换为低磷饮食在91天内并未导致肾钙质沉着症程度降低。因此，磷诱导的肾钙质沉着症在随后的磷限制时可能不会消退。对喂食0.2%或0.6%磷饮食56天的大鼠进行了14个选定变量的临床检查。没有一个变量能够区分有或没有肾钙质沉着症的大鼠。这可能意味着雌性大鼠中磷诱导的肾钙质沉着症不会引起明显不适。
