Kulikovskaia N V, Vaneeva T V, Moroz I A, Nosova E Iu, Lazareva O L, Lovacheva O V, Litvinov V I
Probl Tuberk Bolezn Legk. 2005(8):39-42.
The results of examination of 84 patients with tuberculosis of the central nervous system were used to make comparative clinical and laboratory studies. They revealed that lymphocytosis detected in the cerebrospinal fluid (CF), particularly the prevalence of lymphocytes (more than 50%), and decreased levels of chlorides in the cytogram were of value in the comprehensive diagnosis of tuberculous meningitis. The detection of CF Mycobacterium tuberculosis (MBT) (applying the whole currently available set of methods) is an absolute criterion for the diagnosis of tuberculous meningitis (however, with, unfortunately, few number positive results). The detection of mycobacterial DNA, antigens, and tuberculosis antibodies is an impotent component of a diagnostic complex for tuberculous meningitis. The determination of cytosis, protein, glucose, chlorides, lymphocytic subpopulations, soluble gamma-interferon mediators, mycobacteria, DNA, MBT antigens, and tuberculosis antibodies in SF is essential in treating tuberculous meningitis.
对84例中枢神经系统结核患者的检查结果用于进行临床和实验室对比研究。研究发现，脑脊液（CF）中检测到淋巴细胞增多，尤其是淋巴细胞占比超过50%，以及细胞图谱中氯化物水平降低，对结核性脑膜炎的综合诊断具有重要价值。检测脑脊液中的结核分枝杆菌（MBT）（采用目前所有可用方法）是诊断结核性脑膜炎的绝对标准（然而，不幸的是，阳性结果数量很少）。检测分枝杆菌DNA、抗原和结核抗体是结核性脑膜炎诊断综合体系的重要组成部分。测定脑脊液中的细胞增多、蛋白质、葡萄糖、氯化物、淋巴细胞亚群、可溶性γ-干扰素介质、分枝杆菌、DNA、MBT抗原和结核抗体对于治疗结核性脑膜炎至关重要。
