Alemparte Carlos, Blay Gonzalo, Jørgensen Karl Anker
Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
Org Lett. 2005 Oct 13;7(21):4569-72. doi: 10.1021/ol0514653.
[reaction: see text] Silver fluoride and cinchona alkaloids catalyze the diastereo- and enantioselective 1,3-dipolar cycloaddition between azomethine ylides, generated from N-alkylideneglycine esters, and acrylates to give the corresponding endo-adducts. Azomethine ylides derived from aromatic and aliphatic aldehydes react in a highly diastereoselective reaction with good yields and enantioselectivities of the substituted pyrrolidines.
[反应：见正文] 氟化银和金鸡纳生物碱催化由N-亚烷基甘氨酸酯生成的甲亚胺叶立德与丙烯酸酯之间的非对映和对映选择性1,3-偶极环加成反应，生成相应的内型加合物。由芳香族和脂肪族醛衍生的甲亚胺叶立德在高度非对映选择性反应中发生反应，取代吡咯烷的产率和对映选择性良好。
