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手性金属酰胺作为用于不对称[3+2]环加成反应的高活性催化剂的开发。

Development of chiral metal amides as highly reactive catalysts for asymmetric [3 + 2] cycloadditions.

作者信息

Yamashita Yasuhiro, Yoshimoto Susumu, Dutton Mark J, Kobayashi Shū

机构信息

Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

出版信息

Beilstein J Org Chem. 2016 Jul 13;12:1447-52. doi: 10.3762/bjoc.12.140. eCollection 2016.

DOI:10.3762/bjoc.12.140
PMID:27559396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4979734/
Abstract

Highly efficient catalytic asymmetric [3 + 2] cycloadditions using a chiral copper amide are reported. Compared with the chiral CuOTf/Et3N system, the CuHMDS system showed higher reactivity, and the desired reactions proceeded in high yields and high selectivities with catalyst loadings as low as 0.01 mol %.

摘要

报道了使用手性铜酰胺的高效催化不对称[3+2]环加成反应。与手性CuOTf/Et3N体系相比，CuHMDS体系表现出更高的反应活性，并且所需反应在低至0.01 mol%的催化剂负载量下以高收率和高选择性进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6bd/4979734/08491a7b478e/Beilstein_J_Org_Chem-12-1447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6bd/4979734/560483956f09/Beilstein_J_Org_Chem-12-1447-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6bd/4979734/08491a7b478e/Beilstein_J_Org_Chem-12-1447-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6bd/4979734/560483956f09/Beilstein_J_Org_Chem-12-1447-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6bd/4979734/08491a7b478e/Beilstein_J_Org_Chem-12-1447-g002.jpg

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