水中间苯二酚与芳香胺的催化不对称开环反应。
Catalytic asymmetric ring opening of meso-epoxides with aromatic amines in water.
作者信息
Azoulay Stéphane, Manabe Kei, Kobayashi Shü
机构信息
Graduate School of Pharmaceutical Sciences, University of Tokyo, HFRE Division, ERATO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Org Lett. 2005 Oct 13;7(21):4593-5. doi: 10.1021/ol051546z.
[reaction: see text] An operationally simple and environmentally benign protocol for the catalytic asymmetric ring opening of meso-epoxides with aromatic amines has been developed. The reactions proceeded smoothly in the presence of 1 mol % of Sc(OSO3C12H25)3 and 1.2 mol % of a chiral bipyridine ligand in water to afford beta-amino alcohols in high yields with excellent enantioselectivities.
[反应：见正文] 已开发出一种操作简单且环境友好的方法，用于芳香胺催化外消旋环氧化物的不对称开环反应。在1 mol%的Sc(OSO₃C₁₂H₂₅)₃和1.2 mol%的手性联吡啶配体存在下，反应在水中顺利进行，以高收率和优异的对映选择性得到β-氨基醇。
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