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有机催化的不对称去对称化反应：氮丙啶和环氧化物。

Organocatalyzed enantioselective desymmetrization of aziridines and epoxides.

机构信息

Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Changle Xilu 17, Xi-An, 710032, P. R. China.

出版信息

Beilstein J Org Chem. 2013 Aug 15;9:1677-95. doi: 10.3762/bjoc.9.192.

DOI:10.3762/bjoc.9.192
PMID:24062828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3778401/
Abstract

Enantioselective desymmetrization of meso-aziridines and meso-epoxides with various nucleophiles by organocatalysis has emerged as a cutting-edge approach in recent years. This review summarizes the origin and recent developments of enantioselective desymmetrization of meso-aziridines and meso-epoxides in the presence of organocatalysts.

摘要

近年来，通过有机催化对各种亲核试剂进行手性拆分的meso-氮丙啶和meso-环氧化物的对映选择性去对称化已成为一种前沿方法。本综述总结了手性拆分的meso-氮丙啶和meso-环氧化物在有机催化剂存在下的起源和最新发展。

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