Adamo Mauro F A, Donati Donato, Duffy Eleanor F, Sarti-Fantoni Piero
Centre for Synthesis and Chemical Biolog, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Dublin, Ireland.
J Org Chem. 2005 Oct 14;70(21):8395-9. doi: 10.1021/jo051181w.
A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.
开发了一种三组分一锅法（3-MCR），用于从市售原料组装螺异恶唑啉核。这种新方法能高产率地得到标题化合物，且无需使用色谱法。
