Badran K, Malik T H, Belloso A, Timms M S
Department of Otolaryngology, Head and Neck Surgery, Blackburn Royal Infirmary, Lancashire, UK.
Clin Otolaryngol. 2005 Aug;30(4):333-7. doi: 10.1111/j.1365-2273.2005.01019.x.
A prospective non-blinded randomized controlled trial to compare the efficacy of Merocel and RapidRhino nasal packs in the treatment of anterior epistaxis.
Fifty-two consecutive participants admitted with anterior epistaxis refractory to digital pressure or nasal cautery were randomized to treatment using one or other of the nasal packs. Patients who required repacking because of continued bleeding, only the first packs were included in the analysis. Haemostatic properties of the packs were measured by grading bleeding during and after removal of the pack (0-4, where four is uncontrollable) and by noting if the nose was re-packed or not. The difficulty of insertion and removal (graded 0-3 by clinician where 3 is the most difficult) and the participant's perception of discomfort (graded 0-10, where 10 is the worst pain) during insertion and removal of the pack were also measured.
For bleeding, the mean values for Merocel and RapidRhino during packing and after pack removal were not significant (P = 0.38 and 0.82 respectively). The mean values of patient discomfort on insertion were 6.9 and 5.0 (P = 0.01), and for discomfort on removal were 4.6 and 3.4 (P = 0.05) respectively. The mean values of insertion graded by the clinician were 1.7 and 0.9 (P = 0.0003), and for removal were 1.4 and 0.4 (P < 0.0001).
RapidRhino and Merocel are equally effective in the control of anterior epistaxis but RapidRhino is significantly more comfortable for the patient and easier for the healthcare worker during insertion and removal.
一项前瞻性非盲随机对照试验,比较美罗吸切海绵(Merocel)和速鼻止血棉(RapidRhino)鼻填塞物治疗鼻前部出血的疗效。
52例因手指压迫或鼻腔烧灼止血无效而入院的鼻前部出血患者,随机分为使用其中一种鼻填塞物进行治疗。因持续出血而需要重新填塞的患者,仅将首次使用的填塞物纳入分析。通过对填塞物取出过程中和取出后出血情况进行分级(0 - 4级,4级表示出血无法控制)以及记录是否再次填塞来衡量填塞物的止血性能。同时还测量了填塞物插入和取出的难度(由临床医生分级为0 - 3级,3级表示最难)以及患者在填塞物插入和取出过程中对不适的感受(分级为0 - 10级,10级表示最剧烈疼痛)。
对于出血情况,美罗吸切海绵和速鼻止血棉在填塞时和取出后的平均值无显著差异(分别为P = 0.38和P = 0.82)。患者插入时不适的平均值分别为6.9和5.0(P = 0.01),取出时不适的平均值分别为4.6和3.4(P = 0.05)。临床医生对插入难度的平均值分别为1.7和0.9(P = 0.0003),取出难度的平均值分别为1.4和0.4(P < 0.0001)。
速鼻止血棉和美罗吸切海绵在控制鼻前部出血方面同样有效,但速鼻止血棉对患者而言舒适度显著更高,且医护人员在插入和取出时操作更简便。