在拟南芥茎尖中，干细胞稳态与生长动力学可能会解偶联。

Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex.

作者信息

Reddy G Venugopala, Meyerowitz Elliot M

机构信息

California Institute of Technology, Division of Biology, MC 156-29, 1200 East California Boulevard, Pasadena, CA 91125, USA.

出版信息

Science. 2005 Oct 28;310(5748):663-7. doi: 10.1126/science.1116261. Epub 2005 Oct 6.

DOI:10.1126/science.1116261

PMID:16210497

Abstract

The shoot apical meristem (SAM) is a collection of stem cells that resides at the tip of each shoot and provides the cells of the shoot. It is divided into functional regions. The central zone (CZ) at the tip of the meristem is the domain of expression of the CLAVATA3 (CLV3) gene, encoding a putative ligand for a transmembrane receptor kinase, CLAVATA1, active in cells of the rib meristem (RM), located just below the CZ. We show here that CLV3 restricts its own domain of expression (the CZ) by preventing differentiation of peripheral zone cells (PZ), which surround the CZ, into CZ cells and restricts overall SAM size by a separate, long-range effect on cell division rate.

摘要

茎尖分生组织（SAM）是位于每个茎尖的干细胞集合体，为茎提供细胞。它被划分为不同的功能区域。分生组织顶端的中央区（CZ）是CLAVATA3（CLV3）基因的表达区域，该基因编码一种假定的跨膜受体激酶CLAVATA1的配体，CLAVATA1在位于CZ下方的肋状分生组织（RM）细胞中具有活性。我们在此表明，CLV3通过阻止围绕CZ的外周区细胞（PZ）分化为CZ细胞来限制其自身的表达区域（CZ），并通过对细胞分裂速率的另一种远距离效应来限制SAM的整体大小。