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端粒：连接植物和哺乳动物的有序字符串。

Telomeres: an organized string linking plants and mammals.

机构信息

Department of Biology and Biotechnologies "Charles Darwin", Sapienza, University of Rome, Rome, Italy.

CNR Institute of Biology and Pathology, Rome, Italy.

出版信息

Biol Direct. 2024 Nov 20;19(1):119. doi: 10.1186/s13062-024-00558-y.

DOI:10.1186/s13062-024-00558-y
PMID:39568075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11577926/
Abstract

Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which include their composition in multimers of TTAGGG sequences and their protection by specialized proteins. Moreover, given the link between telomeres, on the one hand, and cell proliferation and stemness on the other, we discuss the counterintuitive convergence between plants and mammals in this regard, focusing on the impact of niches on cell stemness. Finally, we suggest that tackling the study of telomere function and cell stemness by taking into consideration both plants and mammals can aid in the understanding of interconnections and contribute to research focusing on aging and organismal lifespan determinants.

摘要

端粒是细胞干性、生物体衰老和寿命的关键决定因素。在此，我们研究了拟南芥、小鼠和人类端粒的相似之处。我们报告了它们的共同特征，包括它们由 TTAGGG 序列的多聚体组成，以及由专门的蛋白质保护。此外，鉴于端粒与细胞增殖和干性之间的联系，我们讨论了植物和哺乳动物在这方面的反直觉趋同，重点讨论了小生境对细胞干性的影响。最后，我们建议通过同时考虑植物和哺乳动物来研究端粒功能和细胞干性，这有助于理解它们之间的相互联系，并有助于研究衰老和生物体寿命决定因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/5ab97b015061/13062_2024_558_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/531ca7d595b6/13062_2024_558_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/9f176b71b932/13062_2024_558_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/b35591f4ba15/13062_2024_558_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/0604a8cb4bd4/13062_2024_558_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/5ab97b015061/13062_2024_558_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/531ca7d595b6/13062_2024_558_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/9f176b71b932/13062_2024_558_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/b35591f4ba15/13062_2024_558_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/0604a8cb4bd4/13062_2024_558_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc7/11577926/5ab97b015061/13062_2024_558_Fig5_HTML.jpg

相似文献

[1]
Telomeres: an organized string linking plants and mammals.

Biol Direct. 2024-11-20

[2]
Extra-telomeric impact of telomeres: Emerging molecular connections in pluripotency or stemness.

J Biol Chem. 2020-7-24

[3]
Telomeres in cancer and ageing.

Philos Trans R Soc Lond B Biol Sci. 2011-1-12

[4]
Telomeres shorten more slowly in long-lived birds and mammals than in short-lived ones.

Proc Biol Sci. 2003-7-7

[5]
Chromatin regulation and non-coding RNAs at mammalian telomeres.

Semin Cell Dev Biol. 2009-10-6

[6]
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination.

Aging Cell. 2011-6-1

[7]
The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging.

Neurosci Biobehav Rev. 2023-9

[8]
Two combinatorial patterns of telomere histone marks in plants with canonical and non-canonical telomere repeats.

Plant J. 2020-5

[9]
Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing "stemness"-related markers.

J Hepatol. 2013-5-14

[10]
Telomeres, aging, and plants: from weeds to Methuselah - a mini-review.

Gerontology. 2010-4-7

引用本文的文献

[1]
Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans.

Biol Direct. 2025-5-21

本文引用的文献

[1]
TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends.

Sci Adv. 2024-6-14

[2]
POT1 recruits and regulates CST-Polα/primase at human telomeres.

Cell. 2024-7-11

[3]
Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.

Plant Mol Biol. 2024-5-30

[4]
The regulations of telomerase reverse transcriptase (TERT) in cancer.

Cell Death Dis. 2024-1-26

[5]
Telomere-specific regulation of TERRA and its impact on telomere stability.

Semin Cell Dev Biol. 2024-4

[6]
The cold-induced factor CBF3 mediates root stem cell activity, regeneration, and developmental responses to cold.

Plant Commun. 2023-11-13

[7]
Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis.

Cell Rep. 2023-8-29

[8]
Patient-derived organoids for precision oncology: a platform to facilitate clinical decision making.

BMC Cancer. 2023-7-22

[9]
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation.

Cell Stem Cell. 2023-5-4

[10]
CD34 positive cells as endothelial progenitor cells in biology and medicine.

Front Cell Dev Biol. 2023-4-17

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