Chasseing A, Sánchez-Negrete M G, Fernández O, Bordenave H, Rumi L S
Consejo Nacional de Investigaciones, Científicas y técnicas (CONICET), República Argentina.
Sangre (Barc). 1992 Apr;37(2):129-31.
The number of bone marrow fibroblast colony-forming cells (CFU-F) were studied in twelve healthy donors, four colon (CP) and nine lung cancer patients (LP). A liquid culture system has been used to characterize human bone marrow CFU-F. The results showed any recognizable CFU-F in three patients with colon cancer and in two patients of the other group. One of the four CP and five of the nine LP presented a CFU-F value of 17 and 2, 8, 22, 29, 32, respectively compared to 65 from normal subjects. Two LP reached normal CFU-F values (normal range = 33-191). These data support the conclusion that the 84.6% of these solid tumor cancer patients study produced less number of proliferative status of fibroblast colony-forming cells.
对12名健康供者、4名结肠癌患者（CP）和9名肺癌患者（LP）的骨髓成纤维细胞集落形成细胞（CFU-F）数量进行了研究。采用液体培养系统对人骨髓CFU-F进行表征。结果显示，3名结肠癌患者和另一组的2名患者中未发现任何可识别的CFU-F。4名CP患者中的1名和9名LP患者中的5名，其CFU-F值分别为17以及2、8、22、29、32，而正常受试者的CFU-F值为65。2名LP患者达到正常CFU-F值（正常范围 = 33 - 191）。这些数据支持以下结论：在这些接受研究的实体肿瘤癌症患者中，84.6%的患者产生的成纤维细胞集落形成细胞增殖状态数量较少。
