Markov A V, Kulikov A M
Izv Akad Nauk Ser Biol. 2005 Jul-Aug(4):389-400.
The distribution of protein domains was analyzed in superkingdoms Archaea, Bacteria, and Eukaryota. About a half of eukaryotic domains have prokaryotic origin. Many domains related to information processing in the nucleocytoplasm were inherited from archaea. Sets of domains associated with metabolism and regulatory and signaling systems were inherited from bacteria. Many signaling and regulatory domains common for bacteria and eukaryotes were responsible for the cellular interaction of bacteria with other components of the microbial community but were involved in coordination of the activity of eukaryotic organelles and cells in multicellular organisms. Many eukaryotic domains of bacterial origin could not originate from ancestral mitochondria and plastids but rather were adopted from other bacteria. An archaeon with the induced incorporation of alien genetic material could be the ancestor of the eukaryotic nucleocytoplasm.
在古菌、细菌和真核生物这几个超界中分析了蛋白质结构域的分布情况。大约一半的真核生物结构域起源于原核生物。许多与核质中信息处理相关的结构域是从古菌继承而来的。与代谢、调节和信号系统相关的结构域集是从细菌继承而来的。细菌和真核生物共有的许多信号和调节结构域负责细菌与微生物群落其他成分之间的细胞相互作用，但在多细胞生物中参与真核细胞器和细胞活性的协调。许多起源于细菌的真核生物结构域并非源自祖先的线粒体和质体，而是从其他细菌中获取的。一个诱导整合了外来遗传物质的古菌可能是真核生物核质的祖先。
